AapCas12b, Active
Recombinant tag-free Alicyclobacillus acidiphilus AapCas12b was expressed in E. coli cells.
Catalog No. C12B1-E311U
Catalog No. Pack Size Price
C12B1-E311U-50 50 pmol $180
C12B1-E311U-100 100 pmol $295
C12B1-E311U-200 200 pmol $525
C12B1-E311U-1000 1000 pmol $1395
C12B1-E311U-BLUK BULK Contact Us


  • SDS

  • Data Sheet
Overview CRISPR (clustered regularly interspaced short palindromic repeat) and their CRISPR-associated (Cas) proteins constitute the adaptive immune system in bacteria (1-2). This system has been redesigned to create an exemplary genome editing tool for application to RNA-based therapeutics development (3). AapCas12b belongs to the type V CRISPR effector, CRISPR-Cas12b/C2c1, and due to its thermostability, it can be used in a wide range of biomedical applications including loop-mediated isothermal amplification (LAMP), mammalian genome editing, and gene activation (4).
Genbank Number WP_067623834
Storage and Stability Store product at –70 Celsius. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles
Purity For specific information on a given lot, see related technical data sheet.
Molecular weight 128kDa
Specific Activity For specific information on a given lot, see related technical data sheet.
  1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.
  2. Lucia C, et al: An ultrasensitive, rapid, and portable coronavirus SARS-CoV-2 sequence detection method based on CRISPR-Cas12. bioRxiv. doi: https://doi.org/10.1101/2020.02.29.971127.
  3. Teng F, et al: Repurposing CRISPR-Cas12b for mammalian genome engineering. Cell discovery. 2018, 4(1):1-5.